Modeling capsid self-assembly: design and analysis
نویسندگان
چکیده
منابع مشابه
Modeling capsid self-assembly: design and analysis.
A series of simulations aimed at elucidating the self-assembly dynamics of spherical virus capsids is described. This little-understood phenomenon is a fascinating example of the complex processes that occur in the simplest of organisms. The fact that different viruses adopt similar structural forms is an indication of a common underlying design, motivating the use of simplified, low-resolution...
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I present a review of the theoretical and computational methodologies that have been used to model the assembly of viral capsids. I discuss the capabilities and limitations of approaches ranging from equilibrium continuum theories to molecular dynamics simulations, and I give an overview of some of the important conclusions about virus assembly that have resulted from these modeling efforts. To...
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Papillomaviruses (PVs) are double stranded (ds)-DNA viruses (~8-kbp), which infect mucosal and cutaneous epithelial cells from various mammalian species, causing tumors in both epithelial cell-types [22, 48-50, 64, 65]. During the early-phase of an HPV infection; the genome is maintained within the basal epithelium establishing the primary infection, while during the latephase, the capsid prote...
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ژورنال
عنوان ژورنال: Physical Biology
سال: 2010
ISSN: 1478-3975
DOI: 10.1088/1478-3975/7/4/045001